San Francisco 49ers

Looking to place bets on the San Francisco 49ers? Bettors in Arizona have access to competitive NFL odds from licensed sportsbooks. We compare moneylines, point spreads, and totals from multiple bookmakers to help you find the best value.

San Francisco 49ers games typically generate strong betting action, especially for division matchups and primetime games. Our odds comparison updates frequently throughout the week, so check back before placing your wagers to ensure you're getting the best available lines in Arizona.